Indianapolis over San Diego (6). The Chargers really didn't show anything last week against Minnesota, and the Colts play both excellent offense and excellent defense. Indy rolls.
Dallas over New York (5). The Giants are a good team, but they're just not as good as Dallas, on either side of the ball. I think the Giants' defensive line will pressure Romo a bit more than he's used to, but I don't think that will be enough to tip the balance of this game.
Buffalo over Miami (4). Marshawn Lynch is going to have a field day in this one.
Detroit over Arizona (3). Eww, ugly game here. Neither team really plays offense or defense especially well, but I'm going with the Lions due to their slight advantages in all facets.
Philadelphia over Washington (2). Neither team is really that good, but Brian Westbrook is going to tear apart the Washington rush defense because McNabb won't be able to hit anyone through the air on the Washington secondary.
Kansas City over Denver (1). The Broncos offense is banged up, and the Holmes/Smith tandem should be an upgrade over the wholly ineffective Larry Johnson. Kansas City's defense should carry them in this one.
Upset Special: Minnesota over Green Bay (-7.0). These teams are close enough together in talent level that I've got to put my hopes on Adrian Peterson for four points this week.